About Us

Developing Breakthrough Treatments for Human Disease

Management Team


Lonnel Coats, President and Chief Executive Officer and Director

Mr. Coats has been our president and chief executive officer and a director since July 2014.  From 1996 through June 2014, Mr. Coats served in a series of leadership positions at Eisai Inc. and Eisai Corporation of North America, most recently as chief executive officer from 2010 to June 2014 and president and chief operating officer from 2004 to 2010.  Prior to joining Eisai, Mr. Coats spent eight years with Janssen Pharmaceuticals, Inc., a division of Johnson & Johnson, where he held a variety of management and sales positions.  Mr. Coats received his B.P.A. from Oakland University.

Pablo Lapuerta, M.D., Executive Vice President and Chief Medical Officer

Dr. Lapuerta has been our executive vice president and chief medical officer since February 2015.  Dr. Lapuerta served as our executive vice president, safety, pharmacovigilance and medical affairs and chief medical officer from August 2014 until February 2015 and was our executive vice president, clinical development and chief medical officer from February 2013 until August 2014 and senior vice president, clinical development and chief medical officer from 2011 until February 2013. From 2009 through 2010, Dr. Lapuerta served as vice president at Bristol-Myers Squibb Company with responsibility for global development of an Alzheimer’s disease drug candidate. From 2007 through 2009, Dr. Lapuerta was senior vice president, clinical strategy and chief medical officer of Cogentus Pharmaceuticals, Inc. and prior to that served in a variety of clinical development leadership roles at Bristol-Myers Squibb, where he worked for 11 years before joining Cogentus. He holds a B.A. in biology from Harvard College and an M.D. from Harvard Medical School.

Alan J. Main, Ph.D., Executive Vice President, CMC and Supply Operations

Alan Main

Dr. Main has been our executive vice president, CMC and supply operations since February 2015.  Dr. Main served as our executive vice president of pharmaceutical research from 2007 until February 2015 and was our senior vice president, Lexicon Pharmaceuticals from 2001 to 2007.  Dr. Main was president and chief executive officer of Coelacanth Corporation, a leader in using proprietary chemistry technologies to rapidly discover new chemical entities for drug development, from 2000 until our acquisition of Coelacanth in 2001.  Dr. Main was formerly senior vice president, U.S. Research at Novartis Pharmaceuticals Corporation, where he worked for 20 years before joining Coelacanth.  Dr. Main holds a B.S. from the University of Aberdeen, Scotland and a Ph.D. in organic chemistry from the University of Liverpool, England and completed postdoctoral studies at the Woodward Research Institute.

Jeffrey L. Wade, J.D., Executive Vice President, Corporate and Administrative Affairs and Chief Financial Officer

Jeff Wade

Mr. Wade has been our executive vice president, corporate and administrative affairs and chief financial officer since February 2015.  Mr. Wade served as our executive vice president, corporate development and chief financial officer from May 2010 until February 2015 and was our executive vice president and general counsel from 2000 until May 2010 and senior vice president and chief financial officer from 1999 to 2000.  From 1988 through 1998, Mr. Wade was a corporate securities and finance attorney with the law firm of Andrews & Kurth L.L.P., for the last two years as a partner, where he represented companies in the biotechnology, information technology and energy industries.  Mr. Wade is a member of the board of directors of the Texas Healthcare and Bioscience Institute.  He received his B.A. and J.D. from the University of Texas.

John P. Northcott, Vice President of Marketing, Commercial Strategy and Operations

Mr. Northcott has been our vice president of marketing, commercial strategy and operations since June 2013.  From May 2011 through May 2013, Mr. Northcott served as International Business Leader for F. Hoffman-La Roche Ltd. with responsibility for the global strategy, commercialization and life cycle management of Avastin, an approved cancer drug product.  From 2007 through May 2011, Mr. Northcott was Oncology Group Product Manager at Roche with responsibility for the commercialization of Avastin in the United States. Prior to joining Roche, Mr. Northcott spent five years in a variety of management and sales positions with Pfizer Inc., Pharmacia Corporation and Merck & Co.  Mr. Northcott received his B.B.A. from St. Francis Xavier University.

James F. Tessmer, Vice President, Finance and Accounting

Jim Tessmer

Mr. Tessmer has been our vice president, finance and accounting since November 2007 and previously served as our senior director of finance from 2004 to November 2007 and director of finance from 2001 to 2004.  From January 1997 to 2001, Mr. Tessmer was assistant controller for Mariner Health Network, Inc. and prior to that served in a variety of financial and accounting management positions for HWC Distribution Corp. and American General Corporation.  Mr. Tessmer is a certified public accountant and received his B.B.A. from the University of Wisconsin – Milwaukee and his M.B.A. from the University of Houston.