J.E. Tarver, T.C. Jessop, M. Carlsen, D.J. Augeri, Q. Fu, J.P. Healy, A. Heim-Riether, A. Xu, J.A. Taylor, M. Shen, P.E. Keyes, S. David Kimball, X.C. Yu, M. Miranda, Q. Liu, J.C. Swaffield, A. Nouraldeen, A.G. Wilson, R. Finch, K. Jhaver, A.M. Foushee, S. Anderson, T. Oravecz, and K.G. Carson, 5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase. Bioorg Med Chem Lett, 2009. Link to Abstract

T.C. Jessop, J.E. Tarver, M. Carlsen, A. Xu, J.P. Healy, A. Heim-Riether, Q. Fu, J.A. Taylor, D.J. Augeri, M. Shen, T.R. Stouch, R.V. Swanson, L.W. Tari, M. Hunter, I. Hoffman, P.E. Keyes, X.C. Yu, M. Miranda, Q. Liu, J.C. Swaffield, S. David Kimball, A. Nouraldeen, A.G. Wilson, A.M. Foushee, K. Jhaver, R. Finch, S. Anderson, T. Oravecz, and K.G. Carson, Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors. Bioorg Med Chem Lett, 2009. Link to Abstract

L.A. Hu, T. Zhou, J. Ahn, S. Wang, J. Zhou, Y. Hu, and Q. Liu, Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligands. Biochem J, 2009. 424(1): p. 39-45. Link to Abstract

H. Jin, G. Cianchetta, A. Devasagayaraj, K. Gu, B. Marinelli, L. Samala, S. Scott, T. Stouch, A. Tunoori, Y. Wang, Y. Zang, C. Zhang, S. David Kimball, A.J. Main, Z.M. Ding, W. Sun, Q. Yang, X.Q. Yu, D.R. Powell, A. Wilson, Q. Liu, and Z.C. Shi, Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors. Bioorg Med Chem Lett, 2009. 19(17): p. 5229-32. Link to abstract

M. Boonen, P. Vogel, K.A. Platt, N. Dahms, and S. Kornfeld, Mice Lacking Mannose 6-Phosphate Uncovering Enzyme Activity Have a Milder Phenotype than Mice Deficient for N-Acetylglucosamine-1-Phosphotransferase Activity. Mol. Biol. Cell, 2009. 20(20): p. 4381-4389. Link to abstract

C. Pappas, A. Turnage, K.S. Frazier, Q. Liu, and P. Brown, LX1032: A potential new therapy for carcinoid syndrome (CS). J Clin Oncol (Meeting Abstracts), 2009. 27(15S): p. e14555-. Link to abstract

E.C. Lee, U. Desai, G. Gololobov, S. Hong, X. Feng, X.C. Yu, J. Gay, N. Wilganowski, C. Gao, L.L. Du, J. Chen, Y. Hu, S. Zhao, L. Kirkpatrick, M. Schneider, B.P. Zambrowicz, G. Landes, D.R. Powell, and W.K. Sonnenburg, Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem, 2009. 284(20): p. 13735-45. Link to abstract

X. Liu, J.A. Kramer, Y. Hu, J.M. Schmidt, J. Jiang, and A.G.E. Wilson, Development of a High-Throughput Human HepG2 Dual Luciferase Assay for Detection of Metabolically Activated Hepatotoxicants and Genotoxicants. International Journal of Toxicology, 2009. 28(3): p. 162-176. Link to abstract

R. Read, G. Hansen, J. Kramer, R. Finch, L. Li, and P. Vogel, Ectonucleoside triphosphate diphosphohydrolase type 5 (Entpd5)-deficient mice develop progressive hepatopathy, hepatocellular tumors, and spermatogenic arrest. Vet Pathol, 2009. 46(3): p. 491-504. Link to abstract

L.A. Hu, P.M. Tang, N.K. Eslahi, T. Zhou, J. Barbosa, and Q. Liu, Identification of Surrogate Agonists and Antagonists for Orphan G-Protein-Coupled Receptor GPR139. J Biomol Screen, 2009: p. 1087057109335744. Link to abstract

W.K. Sonnenburg, D. Yu, E.C. Lee, W. Xiong, G. Gololobov, B. Key, J. Gay, N. Wilganowski, Y. Hu, S. Zhao, M. Schneider, Z.M. Ding, B.P. Zambrowicz, G. Landes, D.R. Powell, and U. Desai, Glycosylphosphatidylinositol-anchored HDL-binding protein stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4. J Lipid Res, 2009. Link to abstract

N.A. Whitlock, B. Harrison, T. Mixon, X.Q. Yu, A. Wilson, B. Gerhardt, D.E. Eberhart, A. Abuin, and D.S. Rice, Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK. J Ocul Pharmacol Ther, 2009. 25(3): p. 187-94. Link to abstract

S.S. Mason, K.B. Baker, K.W. Davis, V.M. Pogorelov, M.M. Malbari, R. Ritter, S.P. Wray, B. Gerhardt, T.H. Lanthorn, and K.V. Savelieva, Differential sensitivity to SSRI and tricyclic antidepressants in juvenile and adult mice of three strains. Eur J Pharmacol, 2009. 602(2-3): p. 306-15. Link to abstract

J.T. Bagdanoff, M.S. Donoviel, A. Nouraldeen, J. Tarver, Q. Fu, M. Carlsen, T.C. Jessop, H. Zhang, J. Hazelwood, H. Nguyen, S.D.P. Baugh, M. Gardyan, K.M. Terranova, J. Barbosa, J. Yan, M. Bednarz, S. Layek, L.F. Courtney, J. Taylor, A.M. Digeorge-Foushee, S. Gopinathan, D. Bruce, T. Smith, L. Moran, E. O’Neill, J. Kramer, Z. Lai, S.D. Kimball, Q. Liu, W. Sun, S. Yu, J. Swaffield, A. Wilson, A. Main, K.G. Carson, T. Oravecz, and D.J. Augeri, Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders. Journal of Medicinal Chemistry, 2009. 52(13): p. 3941-3953. Link to abstract

N.C. Goodwin, R. Mabon, B.A. Harrison, M.K. Shadoan, Z.Y. Almstead, Y. Xie, J. Healy, L.M. Buhring, C.M. DaCosta, J. Bardenhagen, F. Mseeh, Q. Liu, A. Nouraldeen, A.G.E. Wilson, S.D. Kimball, D.R. Powell, and D.B. Rawlins, Novel l-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes. Journal of Medicinal Chemistry, 2009. 52(20): p. 6201-6204. Link to abstract

B.A. Harrison, N.A. Whitlock, M.V. Voronkov, Z.Y. Almstead, K.-j. Gu, R. Mabon, M. Gardyan, B.D. Hamman, J. Allen, S. Gopinathan, B. McKnight, M. Crist, Y. Zhang, Y. Liu, L.F. Courtney, B. Key, J. Zhou, N. Patel, P.W. Yates, Q. Liu, A.G.E. Wilson, S.D. Kimball, C.E. Crosson, D.S. Rice, and D.B. Rawlins, Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma. Journal of Medicinal Chemistry, 2009. Link to abstract

G. Sumara, I. Formentini, S. Collins, I. Sumara, R. Windak, B. Bodenmiller, R. Ramracheya, D. Caille, H. Jiang, K.A. Platt, P. Meda, R. Aebersold, P. Rorsman, and R. Ricci, Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell, 2009. 136(2): p. 235-48. Link to abstract

L. Shan, X.C. Yu, Z. Liu, Y. Hu, L.T. Sturgis, M.L. Miranda, and Q. Liu, The Angiopoietin-like Proteins ANGPTL3 and ANGPTL4 Inhibit Lipoprotein Lipase Activity through Distinct Mechanisms. J Biol Chem, 2009. 284(3): p. 1419-24. Link to abstract

X.C. Yu, W. Zhang, A. Oldham, E. Buxton, S. Patel, N. Nghi, D. Tran, T.H. Lanthorn, C. Bomont, Z.C. Shi, and Q. Liu, Discovery and characterization of potent small molecule inhibitors of the high affinity proline transporter. Neurosci Lett, 2009. Link to abstract

P. Keyes, G. Hernandez, G. Cianchetta, J. Robinson, and B. Lefebvre, Automated compound verification using 2D-NMR HSQC data in an open-access environment. Magn Reson Chem, 2009. 47(1): p. 38-52. Link to abstract

P. Vogel, M.S. Donoviel, R. Read, G.M. Hansen, J. Hazlewood, S.J. Anderson, W. Sun, J. Swaffield, and T. Oravecz, Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. PLoS ONE, 2009. 4(1): p. e4112. Link to abstract

K.V. Savelieva, S. Zhao, V.M. Pogorelov, I. Rajan, Q. Yang, E. Cullinan, and T.H. Lanthorn, Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS ONE, 2008. 3(10): p. e3301. Link to abstract

G.M. Hansen, D.C. Markesich, M.B. Burnett, Q. Zhu, K.M. Dionne, L.J. Richter, R.H. Finnell, A.T. Sands, B.P. Zambrowicz, and A. Abuin, Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res, 2008. 18(10): p. 1670-9. Link to abstract

R. Brommage, U. Desai, J.P. Revelli, D.B. Donoviel, G.K. Fontenot, C.M. Dacosta, D.D. Smith, L.L. Kirkpatrick, K.J. Coker, M.S. Donoviel, D.E. Eberhart, K.H. Holt, M.R. Kelly, W.J. Paradee, A.V. Philips, K.A. Platt, A. Suwanichkul, G.M. Hansen, A.T. Sands, B.P. Zambrowicz, and D.R. Powell, High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes. Obesity (Silver Spring), 2008. 16(10): p. 2362-7. Link to abstract

X. Liu, J.A. Kramer, J.C. Swaffield, Y. Hu, G. Chai, and A.G. Wilson, Development of a highthroughput yeast-based assay for detection of metabolically activated genotoxins. Mutat Res, 2008. 653(1-2): p. 63-9. Link to abstract

T.H. Lanthorn. Knockout Mice Can Predict Therapeutic and Non-therapeutic Effects of Modulation of Known and Novel Drug Targets. Annual Meeting of the Society of Toxicology. 2008. Seattle, WA.

P. Vogel, R.W. Read, R.B. Vance, K.A. Platt, K. Troughton, and D.S. Rice, Ocular albinism and hypopigmentation defects in Slc24a5-/- mice. Vet Pathol, 2008. 45(2): p. 264-79. Link to abstract

K.V. Savelieva, I. Rajan, K.B. Baker, P. Vogel, W. Jarman, M. Allen, and T.H. Lanthorn, Learning and memory impairment in Eph receptor A6 knockout mice. Neurosci Lett, 2008. 438(2): p. 205-9. Link to abstract

W. Zhang, I. Rajan, K.V. Savelieva, C.Y. Wang, P. Vogel, M. Kelly, N. Xu, B. Hasson, W. Jarman, and T.H. Lanthorn, Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness. Genes Brain Behav, 2008. 7(4): p. 385-92. Link to abstract

K.V. Savelieva, S. Zhao, V.M. Pogorelov, I. Rajan, Q. Yang, E. Cullinan, and T.H. Lanthorn. Generation and Characterization of TPH1, TPH2 and TPH1/TPH2 Deficient Mice. International Behavioral Neuroscience Society Conference. 2008. St. Thomas, Virgin Islands.

V.M. Pogorelov, K.V. Savelieva, S. Zhou, I. Rajan, Q. Yang, E. Cullinan, and T.H. Lanthorn. Creation and phenotypes of TPH1, TPH2 and TPH1/TPH2 DKO deficient mice. Federation of European Pharmaceutical Societies Serotonin Club. 2008. Manchester, UK.

Z.C. Shi, A. Devasagayaraj, K. Gu, H. Jin, B. Marinelli, L. Samala, S. Scott, T. Stouch, A. Tunoori, Y. Wang, Y. Zang, C. Zhang, S.D. Kimball, A.J. Main, W. Sun, Q. Yang, A. Nouraldeen, X.Q. Yu, E. Buxton, S. Patel, N. Nguyen, J. Swaffield, D.R. Powell, A. Wilson, and Q. Liu, Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders. J Med Chem, 2008. 51(13): p. 3684-7. Link to abstract

L.A. Hu, T. Zhou, B.D. Hamman, and Q. Liu, A Homogeneous G Protein-Coupled Receptor Ligand Binding Assay Based on Time-Resolved Fluorescence Resonance Energy Transfer. Assay Drug Dev Technol, 2008. Link to abstract

A. Whitlock, B. McKnight, and D.S. Rice. Increased Intraocular Pressure in Mice Treated with Dexamethasone. Association for Research in Vision and Ophthalmology. 2008. Fort Lauderdale, FL.

D.S. Rice, K. Paes, D.C. Markesich, T. Perry, D.W. Walke, and B. Zambrowicz, Large Scale Screen to Identify Genes Implicated in Vascular Biology in Mammals. 2008. Association for Research in Vision and Ophthalmology. 2008. Fort Lauderdale, FL.

P.M. Brown, X.Q. Yu, K.V. Savelieva, M. Childers, K.S. Frazier, D.W. Walke, A.G.E. Wilson, W.E. Heydorn, and T.H. Lanthorn. LX6171: A Novel Potential Treatment for Cognitive Disorders. American Academy of Neurology. 2008. Chicago, IL.

S. Hong, P. Logan, J. Chen, G. Landes, and B. Zambrowicz. Screening of Mouse Knockouts for Inactivated Genes That Increase Smn Protein Expression. American Academy of Neurology. 2008. Chicago, IL.

Q. Liu, Q. Yang, W. Sun, P. Vogel, W. Heydorn, X.Q. Yu, Z. Hu, W. Yu, B. Jonas, R. Pineda, V. Calderon-Gay, M. Germann, E. O'Neill, R. Brommage, E. Cullinan, K. Platt, A. Wilson, D. Powell, A. Sands, B. Zambrowicz, and Z.C. Shi, Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract. J Pharmacol Exp Ther, 2008. 325(1): p. 47-55. Link to abstract

T.C. Jessop, J.E. Tarver, A.M. Digeorge Foushee, K.G. Jhaver, J.A. Taylor, X. Xu, Q. Fu, M. Carlsen, M. Shen, X.C. Yu, Z. Liu, M.L. Miranda, A. Nouraldeen, X.Q. Yu, L.W. Tari, M.J. Hunter, I.D. Hoffman, A.G.E. Wilson, S.J. Anderson, T. Oravecz, T. Stouch, D.J. Augeri, and K.G. Carson. Lead Optimization and Structure-Based Design of Deoxycytidine Kinase Inhibitors with Potent In Vitro and In Vivo Activity. National Meeting of the American Chemical Society. 2008. Philadelphia, PA.

V.M. Pogorelov, K.B. Baker, M.M. Malbari, T.H. Lanthorn, and K.V. Savelieva, Chapter 2: A Standardized Behavioral Test Battery to Identify and Validate Targets for Neuropsychiatric Diseases and Pain., in Experimental Animal Models in Neurobehavioral Research, A.V. Kalueff and J.L. LaPorte, Editors. 2008, Laboratory of Clinical Science, Nat. Inst. of Mental Health: Bethesda, MD.

W.S. Lee, B.J. Payne, C.M. Gelfman, P. Vogel, and S. Kornfeld, Murine UDP-GlcNAc:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase lacking the gamma-subunit retains substantial activity toward acid hydrolases. J Biol Chem, 2007. 282(37): p. 27198-203. Link to abstract

P.M. Brown, J.I. Jackson, K.S. Frazier, C.A. Turner, Z.C. Shi, and Q. Liu. From Mouse Knockout to Investigational Drug: LX1031, A Novel Potential Treatment for Irritable Bowel Syndrome. American College of Gastroenterology. 2007. Philadelphia, PA.

C.M. Gelfman, P. Vogel, T.M. Issa, C.A. Turner, W.S. Lee, S. Kornfeld, and D.S. Rice, Mice lacking alpha/beta subunits of GlcNAc-1-phosphotransferase exhibit growth retardation, retinal degeneration, and secretory cell lesions. Invest Ophthalmol Vis Sci, 2007. 48(11): p. 5221-8. Link to abstract

V.M. Pogorelov, T.H. Lanthorn, and K.V. Savelieva, Use of a platform in an automated open-field to enhance assessment of anxiety-like behaviors in mice. J Neurosci Methods, 2007. 162(1-2): p. 222-8. Link to abstract

U.T. Iwaniec, T.J. Wronski, J. Liu, M.F. Rivera, R.R. Arzaga, G. Hansen, and R. Brommage, PTH stimulates bone formation in mice deficient in Lrp5. J Bone Miner Res, 2007. 22(3): p. 394-402. Link to abstract

R. Brommage, J. Liu, J.P. Revelli, L.L. Kirkpatrick, and D.R. Powell, Gene Knockouts of Wnt 10b and Wnt16 in Mice Result in Low Bone Mass, in International Bone & Mineral Society. 2007: Montreal, Quebec, Canada.

S.J. Anderson, J.P. Holst Lauritsen, M.G. Hartman, A.M. Digeorge Foushee, J.M. Lefebvre, S.A. Shinton, B. Gerhardt, R.R. Hardy, T. Oravecz, and D.L. Wiest, Ablation of Ribosomal Protein L22 Selectively Impairs alphabeta T Cell Development by Activation of a p53-Dependent Checkpoint. Immunity, 2007. 26: p. 1-14. Link to abstract

M.K. Shadoan, K. Kavanagh, L. Zhang, M.S. Anthony, and J.D. Wagner, Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue. Metabolism, 2007. 56(6): p. 830-7. Link to abstract

U. Desai, E.C. Lee, K. Chung, C. Gao, J. Gay, B. Key, G. Hansen, D. Machajewski, K.A. Platt, A.T. Sands, M. Schneider, I. Van Sligtenhorst, A. Suwanichkul, P. Vogel, N. Wilganowski, J. Wingert, B.P. Zambrowicz, G. Landes, and D.R. Powell, Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci U S A, 2007. 104(28): p. 11766-71. Link to abstract

T. Oravecz, M.S. Donoviel, S.J. Anderson, K. Carson, W. Sun, J. Swaffield, Q. Liu, S.D. Kimball, J.R. Piggott, A.J. Main, B.P. Zambrowicz, A.T. Sands, C.A. Turner, and D.J. Augeri. Genetic and Chemical Inhibition of Sphingosine-1-Phosphate Lyase Results in Peripheral Lymphopenia and Alleviates Disease Development in Animal Models of Inflamation and Autoimmunity. 49th Annual Meeting of the American Society of Hematology. 2007. Atlanta, GA.

Z.C. Shi. Modulation of Peripheral Serotonin Levels by Inhibitors of Tryptophan Hydroxylase 1 for the Potential Treatment of Irritable Bowel Syndrome (IBS). 234th National Meeting of the American Chemical Society. 2007. Boston, MA.

J.A. Kramer, J.E. Sagartz, and D.L. Morris, The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nat Rev Drug Discov, 2007. 6(8): p. 636-49. Link to abstract

M. Schmidt, K. Paes, A. De Maziere, T. Smyczek, S. Yang, A. Gray, D. French, I. Kasman, J. Klumperman, D.S. Rice, and W. Ye, EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development, 2007. 134(16): p. 2913-23. Link to abstract

K. Salojin and T. Oravecz, Regulation of innate immunity by MAPK dual-specificity phosphatases: knockout models reveal new tricks of old genes. J Leukoc Biol, 2007. 81(4): p. 860-9. Link to abstract

A. Abuin, G.M. Hansen, and B. Zambrowicz, Gene trap mutagenesis. Handb Exp Pharmacol, 2007(178): p. 129-47. Link to abstract

B.P. Zambrowicz, K.H. Holt, D.W. Walke, L.L. Kirkpatrick, and D.E. Eberhart, Chapter 1: Generation of Transgenic Animals, in Target Validation in Drug Discovery, B.W. Metcalf and S. Dillon, Editors. 2007, Academic Press: Burlington, MA.

J. Schmidt, A. Sun, C. Cruz, L. Li, and L. Moran. Optimization of Linear Ion Trap Mass Spectrometer for Structural Elucidation of Metabolites. American Society for Mass Spectrometry Annual Conference. 2006. Seattle, WA.

S. Zhao, J. Edwards, J. Carroll, L. Wiedholz, R.A. Millstein, C. Jaing, D.L. Murphy, T.H. Lanthorn, and A. Holmes, Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice. Neuroscience, 2006. 140(1): p. 321-34. Link to abstract

K.V. Salojin, I.B. Owusu, K.A. Millerchip, M. Potter, K.A. Platt, and T. Oravecz, Essential role of MAPK phosphatase-1 in the negative control of innate immune responses. J Immunol, 2006. 176(3): p. 1899-907. Link to abstract

J.W. Davis and J.A. Kramer, Genomic-based biomarkers of drug-induced nephrotoxicity. Expert Opin Drug Metab Toxicol, 2006. 2(1): p. 95-101. Link to abstract

D.R. Powell, Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo. Obes Rev, 2006. 7(1): p. 89-108. Link to abstract

J.J. Schrick, P. Vogel, A. Abuin, B. Hampton, and D.S. Rice, ADP-ribosylation factor-like 3 is involved in kidney and photoreceptor development. Am J Pathol, 2006. 168(4): p. 1288-98. Link to abstract

R. Brommage, J. Liu, A. Suwanichkul, and D.R. Powell, High bone mass in sclerostin-deficient knockout mice. Journal of Musculoskeletal and Neuronal Interactions, 2006. 6(4): p. 392.

A. Heim-Riether and J. Healy, A novel method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-ones. J Org Chem, 2005. 70(18): p. 7331-7. Link to abstract

D.P. Rotella, American Chemical Society - 229th National Meeting: bench to pilot plant. IDrugs, 2005. 8(5): p. 390-1. Link to abstract

D.P. Rotella, American Chemical Society - 229th National Meeting: carbohydrate vaccines. IDrugs, 2005. 8(5): p. 387-9. Link to abstract

D.R. Powell, U. Desai, M.J. Sparks, G. Hansen, J. Gay, J. Schrick, Z.Z. Shi, J. Hicks, and P. Vogel, Rapid development of glomerular injury and renal failure in mice lacking p53R2. Pediatr Nephrol, 2005. 20(3): p. 432-40. Link to abstract

C.P. Cruz, J.M. Schmidt, and A. Nouraldeen. High Throughput Quantitation of Small Molecules in Biological Fluids. American Society for Mass Spectrometry Annual Conference. 2005. San Antonio, TX.

P. Vogel, W.M. Kell, D.L. Fritz, M.D. Parker, and R.J. Schoepp, Early events in the pathogenesis of eastern equine encephalitis virus in mice. Am J Pathol, 2005. 166(1): p. 159-71. Link to abstract

M. Yaneva, H. Li, T. Marple, and P. Hasty, Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. Nucleic Acids Res, 2005. 33(16): p. 5320-30. Link to abstract

D.S. Rice, W. Huang, H.A. Jones, G. Hansen, G.L. Ye, N. Xu, E.A. Wilson, K. Troughton, K. Vaddi, R.C. Newton, B.P. Zambrowicz, and A.T. Sands, Severe retinal degeneration associated with disruption of semaphorin 4A. Invest Ophthalmol Vis Sci, 2004. 45(8): p. 2767-77. Link to abstract

D.P. Rotella, American Chemical Society--228th National Meeting. Wolfrom/Isbell New Investigator Award Symposium. IDrugs, 2004. 7(10): p. 893-4. Link to abstract

D.P. Rotella, American Chemical Society--228th National Meeting. Technical achievements in organic synthesis. 22-26 August 2004, Philadelphia, PA, USA. IDrugs, 2004. 7(10): p. 889-92. Link to abstract

D.P. Rotella, American Chemical Society--227th Annual Meeting. NMDA receptor. 28 March - 1 April 2004, Anaheim, CA, USA. IDrugs, 2004. 7(5): p. 433-5. Link to abstract

D.P. Rotella, American Chemical Society--227th annual meeting. Neuroprotection. 28 March - 1 April 2004, Anaheim, CA, USA. IDrugs, 2004. 7(5): p. 430-2. Link to abstract

D.P. Rotella, American Chemical Society--227th annual meeting. Diabetes. 28 March - 1 April 2004, Anaheim, CA, USA. IDrugs, 2004. 7(5): p. 428-9. Link to abstract

D.P. Rotella, SB-480848. GlaxoSmithKline. Curr Opin Investig Drugs, 2004. 5(3): p. 348-51. Link to abstract

D.P. Rotella, Novel "second-generation" approaches for the control of type 2 diabetes. J Med Chem, 2004. 47(17): p. 4111-2. Link to abstract

B.P. Zambrowicz and A.T. Sands, Modeling drug action in the mouse with knockouts and RNA interference. Drug Discovery Today: TARGETS, 2004. 3(5): p. 198-207. Link to abstract

R. Brommage, Validation and calibration of DEXA body composition in mice. Am J Physiol Endocrinol Metab, 2003. 285(3): p. E454-9. Link to abstract

B.P. Zambrowicz, C.A. Turner, and A.T. Sands, Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry. Curr Opin Pharmacol, 2003. 3(5): p. 563-70. Link to abstract

G. Donoho, M.A. Brenneman, T.X. Cui, D. Donoviel, H. Vogel, E.H. Goodwin, D.J. Chen, and P. Hasty, Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer, 2003. 36(4): p. 317-31. Link to abstract

B.P. Zambrowicz and A.T. Sands, Knockouts model the 100 best-selling drugs--will they model the next 100? Nat Rev Drug Discov, 2003. 2(1): p. 38-51. Link to abstract

B.P. Zambrowicz, A. Abuin, R. Ramirez-Solis, L.J. Richter, J. Piggott, H. BeltrandelRio, E.C. Buxton, J. Edwards, R.A. Finch, C.J. Friddle, A. Gupta, G. Hansen, Y. Hu, W. Huang, C. Jaing, B.W. Key, Jr., P. Kipp, B. Kohlhauff, Z.Q. Ma, D. Markesich, R. Payne, D.G. Potter, N. Qian, J. Shaw, J. Schrick, Z.Z. Shi, M.J. Sparks, I. Van Sligtenhorst, P. Vogel, W. Walke, N. Xu, Q. Zhu, C. Person, and A.T. Sands, Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A, 2003. 100(24): p. 14109-14. Link to abstract

G. Donoho and P. Hasty, High-throughput inducible expression of transgenes at the Hprt gene in mouse embryonic stem cells. Biotechniques, 2003. 34(3): p. 462-4, 466, 468. Link to abstract

C.J. Friddle, A. Abuin, R. Ramirez-Solis, L.J. Richter, E.C. Buxton, J. Edwards, R.A. Finch, A. Gupta, G. Hansen, K.H. Holt, Y. Hu, W. Huang, C. Jaing, B.W. Key, Jr., P. Kipp, B. Kohlhauff, Z.Q. Ma, D. Markesich, M. Newhouse, T. Perry, K.A. Platt, D.G. Potter, N. Qian, J. Shaw, J. Schrick, Z.Z. Shi, M.J. Sparks, D. Tran, E.R. Wann, W. Walke, J.D. Wallace, N. Xu, Q. Zhu, C. Person, A.T. Sands, and B.P. Zambrowicz, High-throughput mouse knockouts provide a functional analysis of the genome. Cold Spring Harb Symp Quant Biol, 2003. 68: p. 311-5. Link to abstract

H. BeltrandelRio, F. Kern, T.H. Lanthorn, T. Oravecz, J. Piggott, D. Powell, R. Ramirez-Solis, A. Sands, and B. Zambrowicz, Saturation Screening of the Druggable Mammalian Genome, in Model Organisms in Drug Discovery, P.M. Carroll and K. Fitzgerald, Editors. 2003, John Wiley & Sons, Ltd. p. 251-278.

R.A. Finch, D.B. Donoviel, D. Potter, M. Shi, A. Fan, D.D. Freed, C.Y. Wang, B.P. Zambrowicz, R. Ramirez-Solis, A.T. Sands, and N. Zhang, mdmx is a negative regulator of p53 activity in vivo. Cancer Res, 2002. 62(11): p. 3221-5. Link to abstract

A. Abuin, K.H. Holt, K.A. Platt, A.T. Sands, and B.P. Zambrowicz, Full-speed mammalian genetics: in vivo target validation in the drug discovery process. Trends Biotechnol, 2002. 20(1): p. 36-42. Link to abstract

L. Chen and D.J. Waxman, Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer. Curr Pharm Des, 2002. 8(15): p. 1405-16. Link to abstract

D.W. Walke, C. Han, J. Shaw, E. Wann, B. Zambrowicz, and A. Sands, In vivo drug target discovery: identifying the best targets from the genome. Curr Opin Biotechnol, 2001. 12(6): p. 626-31. Link to abstract

D.B. Donoviel, D.D. Freed, H. Vogel, D.G. Potter, E. Hawkins, J.P. Barrish, B.N. Mathur, C.A. Turner, R. Geske, C.A. Montgomery, M. Starbuck, M. Brandt, A. Gupta, R. Ramirez-Solis, B.P. Zambrowicz, and D.R. Powell, Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol, 2001. 21(14): p. 4829-36. Link to abstract

D.S. Lim, H. Vogel, D.M. Willerford, A.T. Sands, K.A. Platt, and P. Hasty, Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol, 2000. 20(11): p. 3772-80. Link to abstract

F. Wattler, S. Wattler, M. Kelly, H.B. Skinner, and M. Nehls, Cloning, chromosomal location, and expression analysis of murine Smarce1-related, a new member of the high-mobility 365 group gene family. Genomics, 1999. 60(2): p. 172-8. Link to abstract

S. Wattler, M. Kelly, and M. Nehls, Construction of gene targeting vectors from lambda KOS genomic libraries. Biotechniques, 1999. 26(6): p. 1150-6, 1158, 1160. Link to abstract

M. Morimatsu, G. Donoho, and P. Hasty, Cells deleted for Brca2 COOH terminus exhibit hypersensitivity to gamma-radiation and premature senescence. Cancer Res, 1998. 58(15): p. 3441-7. Link to abstract

B.P. Zambrowicz, G.A. Friedrich, E.C. Buxton, S.L. Lilleberg, C. Person, and A.T. Sands, Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature, 1998. 392(6676): p. 608-11. Link to abstract

B.P. Zambrowicz and G.A. Friedrich, Comprehensive mammalian genetics: history and future prospects of gene trapping in the mouse. Int J Dev Biol, 1998. 42(7): p. 1025-36. Link to abstract

G.A. Friedrich, Moving beyond the genome projects. Nat Biotechnol, 1996. 14(10): p. 1234-7. Link to abstract

R. Burgess, A. Rawls, D. Brown, A. Bradley, and E.N. Olson, Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature, 1996. 384(6609): p. 570-3. Link to abstract